Department of Otorhinolaryngology, Nagoya City University Medical School
Department of Otorhinolaryngology, Nagoya City University Medical School
Department of Otorhinolaryngology, Nagoya City University Medical School
Department of Otorhinolaryngology, Asahikawa Medical College
Department of Otorhinolaryngology, Asahikawa Medical College
Department of Otorhinolaryngology, Asahikawa Municipal Hospital
Department of Otorhinolaryngology, Sapporo National Hospital
Department of Otorhinolaryngology, Sapporo Kosei Hospital
Department of Otorhinolaryngology, Seibokai Tenshi Hospital
Department of Otorhinolaryngology, Akita University, School of Medicine
Department of Otorhinolaryngology, Akita University, School of Medicine
Department of Otorhinolaryngology, Akita Kumiai General Hospital
Department of Otorhinolaryngology, Akita Kumiai General Hospital
Department of Otorhinolaryngology, Tohoku University, School of Medicine
Department of Otorhinolaryngology, Tohoku University, School of Medicine
Department of Otorhinolaryngology, Tohoku Rosai Hospital
Department of Otorhinolaryngology, Tohoku Rosai Hospital
Department of Otorhinolaryngology, Tohoku Kosai Hospital
Department of Otorhinolaryngology, School of Medicine, Gunma University
Department of Otorhinolaryngology, Juntendo University, School of Medicine
Department of Otorhinolaryngology, Juntendo University, School of Medicine
Department of Otorhinolaryngology, Koto Hospital
Department of Otorhinolaryngology, Katsunan Hospital
Department of Otorhinolaryngology, Tokyo Women's Medical College
Department of Otorhinolaryngology, Tokyo Women's Medical College
Department of Otorhinolaryngology, The Jikei University, School of Medicine
Department of Otorhinolaryngology, The Jikei University, School of Medicine
Department of Otorhinolaryngology, Ota General Hospita1
Department of Otorhinolaryngology, Ota General Hospita1
Department of Otorhinolaryngology, Tokai University, School of Medicine
Department of Otorhinolaryngology, Tokai University, School of Medicine
Department of Otorhinolaryngology, Tokai University Oiso Hospital
Department of Otorhinolaryngology, Tokai University Tokyo Hospital
Department of Otorhinolaryngology, Tokai University Tokyo Hospital
Department of Otorhinolaryngology, Isehara Kyodo Hospital
Department of Otorhinolaryngology, Tanashi Hospital
Department of Otorhinolaryngology, Tanashi Hospital
Department of Otorhinolaryngology, Nippon Kokan Hospita1
Department of Otorhinolaryngology, Nippon Kokan Hospita1
Department of Otorhinolaryngology, Kosei Hospital
Department of Otorhinolaryngology, Kosei Hospital
Department of Otorhinolaryngology, Showa Hospital
Department of Otorhinolaryngology, Showa Hospital
Department of Otorhinolaryngology, Ichinomiya City Hospital
Department of Otorhinolaryngology, Kasugai City Hospital
Department of Otorhinolaryngology, Kamo Hospital
Department of Otorhinolaryngology, Fujita-Gakuen Health University, School of Medicine
Department of Otorhinolaryngology, Fujita-Gakuen Health University, School of Medicine
Department of Otorhinolaryngology, School of Medicine, Mie University
Department of Otorhinolaryngology, School of Medicine, Mie University
Department of Otorhinolaryngology, Yamamoto General Hospital
Department of Otorhinolaryngology, Ise City General Hospital
Department of Otorhinolaryngology, Osaka City University, Medical School
Department of Otorhinolaryngology, Osaka City University, Medical School
Department of Otorhinolaryngology, Osaka City University, Medical School
Department of Otorhinolaryngology, Osaka Medical College
Department of Otorhinolaryngology, Osaka Medical College
Department of Otorhinolaryngology, Hokusetsu Hospital
Department of Otorhinolaryngology, Hokusetsu Hospital
Department of Otorhinolaryngology, Osaka Municipal Shirokita City Hospital, 0saka 535, Japan
Department of Otorhinolaryngology, Osaka Municipal Shirokita City Hospital, 0saka 535, Japan
Department of Otorhinolaryngology, Hyogo Medical College
Department of Otorhinolaryngology, Hyogo Medical College
Department of Otorhinolaryngology, Takarazuka City Hospital
Department of Otorhinolaryngology, Ehime University, School of Medicine
Department of Otorhinolaryngology, Ehime University, School of Medicine
Department of Otorhinolaryngology, Ehime Prefectural Central Hospital
Department of Otorhinolaryngology, Kawasaki Medical Schoo1, Faculty of Medicine
Department of Otorhinolaryngology, Kawasaki Medical Schoo1, Faculty of Medicine
Department of Otorhinolaryngology, Hiroshima University, School of MediCine
Department of Otorhinolaryngology, Hiroshima University, School of MediCine
Department of Otorhinolaryngology, Hiroshima Red Cross Hospital
Department of Otorhinolaryngology, Onomichi General Hospital
Department of Otorhinolaryngology, Yamaguchi Univercity, School of Medicine
Department of Otorhinolaryngology, Yamaguchi Univercity, School of Medicine
Department of Otorhinolaryngology, Saga Medical School, Faculty of Medicine
Department of Otorhinolaryngology, Saga Medical School, Faculty of Medicine
Department of Otorhinolaryngology, Medical College of Oita, School of Medicine
Department of Otorhinolaryngology, Medical College of Oita, School of Medicine
Department of Otorhinolaryngology, Medical College of Oita, School of Medicine
Department of Otorhinolaryngology, Oita Prefectural Hospital
Department of Otorhinolaryngology, Oita Prefectural Hospital
Department of Otorhinolaryngology, Kumamoto University Medical School
Department of Otorhinolaryngology, Kumamoto University Medical School
Department of Otorhinolaryngology, Faculty of Medicine, Kagoshima University
Department of Otorhinolaryngology, Faculty of Medicine, Kagoshima University
Department of Otorhinolaryngology, Faculty of Medicine, Kagoshima University
Department of Otorhinolaryngology, Kagoshima Seikyo Hospital
Department of Otorhinolaryngology, General Hospital Founded by Kimotsuki Country Doctor's Association
Department of Pharmacology, Hamamatsu University, School of Medicine
1988 Volume 34 Issue 1 Pages 33-47
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In order to evaluate the clinical usefulness of carbocisteine (S-CMC) in the treatment of chronic paranasal sinusitis, a double blind trial was carried out by comparing S-CMC with L-cysteine ethylester hydrochloride (L-cysteine) as a control drug. S-CMC group (S-Group) was administered orally two tablets of S-CMC and one placebo tablet in place of active L-cysteine (1,500mg of S-CMC/day), and L-cysteine group (L-Group) one tablet of L-cysteine and two placebo tablets in place of active S-CMC (300mg of L-cysteine/day) t, i, d, after meal for four weeks. Following results were obtained: 1) The ratio of excellent or good utility of S-Group was significantly higher than that of L-Group. 2) The ratio of marked or moderate improvement of S-Group was significantly higher than that of L-Group. 3) The improvement ratio for subjective and objective symptoms of S-Group was significantly higher than that in L-Group. 4) No significant difference was found in the judgement of X-ray findings between the two groups. 5) In the respective evaluation items classified as subjective symptoms (rhinorrhea, postnasal drip, nasal obstruction) and as objective symptoms (volume of rhinorrhea, mucus rhinorrhea, postnasal drip), S-Group showed significantly superior improvement ratio in those items to L-Group. 6) Side effects were observed in two cases (1.5%) in S-Group and one case (0.8%) in L-Group. The side effects were not serious and disappeared soon after the administration was discontinued. From the above results, it is concluded that S-CMC is highly effective in the treatment of chronic paranasal sinusitis.