Abstract
A continuous cell strain (NPC-TY861) was established from nasopharyngeal carcinoma patients with undifferentiated squamous cell carcinoma. NPC-TY861 grew like a monolayer of epithelioid cells. The average doubling time of this cell line was 18 hrs. The modal chromosome number was 65, with a range of 48 to 70. Immunofluorescence method, NPC-TY861 line were found to be positive for EBNA, VCA and cytokeratin. From these results, this cell line was productive of EBV, in the supernatant of the culture. After the heteroinoculation of this cell line to a BALB/c nude mice, a tumor formed subcutaneously and was histologically similar to a primary tumor in structure.
