jibi to rinsho
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
Clinical evaluation of Cefodizime in the treatment of paranasal sinusitis
Shunkichi BABAJunichiro SHIMADATokuji UNNOYoshihiro NAITOSatoshi NONAKATomonori TAKASAKAShozo KAWAMURATakeshi MARUOAkira TONAIMitsuaki INAGAKIToru MATSUNAGAMinoru ISHIDANaozo TAYAYasuo HARADAShubun TAKEBAYASHITakeo YASHIKIYuko NINOMIYATatsuo YOSHIOKAAkira TAKANOKoji SERATakeshi ARAKIGoro MOGIShigehiro UEYAMAMasaaki KUGAYuichi KURONOMasaru OYAMAKoichi DEGUCHI
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Keywords: Cefodizime
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1989 Volume 35 Issue 1 Pages 166-178

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Abstract
In co-operation with several clinics employing the protocol, a study was conducted to evaluate the clinical effectiveness and safety of Cefodizime (CDZM) in the treatment of paranasal sinusitis. Fifty-four patients over 16 years of age were considered for participation in this study, of which 42 were selected as clinical test subjects. Among those patients, 20 suffered from acute sinusitis and 22 from acute exacerbations of chronic sinusitis. Following treatment with CDZM, the doctor in charge judged the drug clinically efficacious in 75% of cases with acute sinusitis, in 68.2% of cases with acute exacerbations of chronic sinusitis, and in 71.4% of all cases studied. Using unified criteria, drug efficacy was rated at 85% for acute sinusitus, 72.7% for acute exacerbations of chronic sinusitis, and at 78.6% for all cases combined. The rate of bacteriological elimination rate was 92.9% for infections involving a single gram-positive pathogen, 100% each for those involving a single gram- negative orgaism, a single anaerobe, or multiple pathogens, and 97.1% for all pathogens. Side effects included one mild case of diarrhoea and one of nausea with loose stool. Abnormal laboratory test values, involving elevated GOT and GPT levels, were reported in one case only. Based upon the above results, CDZM is considered to be a drug useful in the treatment of paranasal sinusitis.
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