Abstract
Methyl B12 500μg was administrated to 12 patients with bilateral chronic sinusitis who had recieved Caldwell-Luc's operation. At a one week interval, both sides were operated on. Only after the second operation, Methyl B12 500μg was administered twice daily. Spontaneous pain, opressive pain, numbness and swelling were compared for 7 days following the operation on each side. Opressive pain and feeling of disorder on radix dentis were not significantly different between the 2 periods. However, spontaneous pain and swelling were clearly milder during the drug administration period, and significant effectiveness of the drug was recognized statistically. The overall improvement of each symptom was evaluated on the basis of 6 grades by referring to the patient's impression and the doctor's objective observation. As a result, only 4 of 12 were evaluated as “improved” or better when the drug was not administered. In contrast, 11 of 12 patients were evaluated as “improved” or better when the drug was given. Therefore, Methyl B12 is expected to play an important role in the healing of nerve injuries caused by surgery.
