Abstract
The effectiveness of a new nasal spray, SN-A8C, was examined with another nasal spray (Nabel®) in a double blind study. Each bottle was given an idetifying number, but the contents of each were not revealed to the examiner until after the study was completed. Bothe sprays were sprayed into each nasal cavity of six healthy patients. Reactive changes of color and volume of the inferior turbinate were observed at intervals of up to six hours after the application. Also, the subjects' feelings on application of nasal sprays was inquired over a course of time. Results were as follows; (1) The efficacy of reducing redness and volume of the inferior turbinate was almost the same between the two nasal sprays.(2) SN-A8C supassed Nabel in comfort of application.(3) No side effects could be observed with either medicine. Chemically, the main content of SM-A8C is tetrahydrozoline nitrate, which is the same as Nabel. However, gel has been added to SN-A8C, so that the spray remains longer on the surface of the nasal mucous membrane. It was concluded that SN-A8C is useful, because it is effective longer and is more comfortable to use than Nabel. It is recommendable for cases of nasal obstruction.
