Evaluation of the efficacy of Cefuzonam in acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media

A comparative study with Cefotiam

Abstract

The efficacy, safety, and usefulness of Cefuzonam (CZON) was objectively evaluated as a treatment of suppurative otitis media (acute infections and acute exacerbation of chronic infections), using Cefotiam (CTM) as a comparison drug. The dosages used were 1g, IV, bid for 7 days, as a rule. Results were: 1. A clinical efficacy rate was 68.7% (68/99) for CZON and 62.4% (58/93) for CTM as judged by the physicians in charge. The rate was 66.7% (66/99) for CZON and 63.4% (59/93) for CTM when assessed by committee. Neither of these reflects a significant difference between the two groups. When assessed by disease type, the efficacy rate for the CTM group was higher in acute otitis media and that for the CZON group was higher in chronic otitis media, but there was no significant difference. 2. No significant difference in subjective and objective findings was observed on days 3 or 7.3. Bacteriological effect was not significantly different. In total cases, bacterial eradication (excluding bacterial replacement) was noted in 64.0% (55/86) of the CZON group and 58.8% (47/80) of the CTM group. CZON was noted to be significantly superior to CTM in the MIC against S. aureus and all strains isolated prior to drug administration. 4. There was nosignificant difference between the groups in overall safety. Side effects were noted in one patient from each group. Abnormal laboratory values were noted in 4 cases (6.2%) of the CZON group and 2 cases (3.6%) of the CTM group. The difference is not significant. 5. The rate of usefulness was 65.7% (65/99) for the CZON group and 64.5% (60/93) for the CTM group, with no significant difference between the groups. From these results, we conclude that CZON is highly useful for the treatment of suppurative otitis media.