The effect of topical use of antiallergic drugs on reactivity of the nasal mucosa to histamine

Abstract

To evaluate the effect of antiallergic drugs on reactivity of the nasal mucosa to histamine, the amount of nasal secretion and the frequency of sneezing induced by topical application of histamine chloride (0.25%, 20ul) were measured before and after topical use of DSCG or Ketotifen for 4 weeks. Topical use of either DSCG (p<0.05) or Ketotifen (P<0.01) caused a significant decrease in the amount of nasal secretion induced by histamine. Topical use of Ketotifen showed a tendency to reduce the frequency of sneezing induced by histamine (p<0.10).