Clinical efficacy of Ofloxacin otic solution in children with otitis media et externa

Abstract

The efficacy and safety of an otic solution of a new quinolone derivative, ofloxacin (OFLX) was tested in children with external and middle ear inflammations. The results obtained were as follows: 1. The topical administration of 0.3% OFLX solution into the tympanic cavity was effective in 100% of the patients receiving the drug once a day, and in 86.7% of the subjects treated twice a day. 2. Clinical efficacy in patients with external otitis media was 66.7% for cases receiving the drug once a day and 100% for the ones treated twice a day. 3. Bacterial eradication was obtained in 92.9% of the cases receiving the drug once a day, and in 92.4% of the ones receiving it twice a day. 4. No adverse effects were observed in any of the patients. From these results, OFLX otic solution is a very effective and safe topical agent for treating otitis media and otitis media externa in children.