Fundamental and clinical investigation using cefepime (BMY-28142) in otorhinolaryngology

Abstract

A fundamental and clinical investigation was performed using cefepime (BMY-28142, CFPM), a new cephalosporin derivative. The results led to the following conclusions: 1) The antibacterial activity was meassured and compared with ceftazideme (CAZ) and cefuzonam (CZON). CFPM was less effective than CZON against S. aureus, but was more effective than CAZ and CZON against other bacteria. 2) The concentration of CFPM im middle ear mucosa or in the otorrhea was much higher than MIC to all bacteria studied. 3) CFPM was used in 52 cases, and its efficacy rate was 79.2%. 4) The rate of bacterial eradication was 85.2% in otitis media and 100% in sinusitis and tonsillitis. 5) In one case, the side effect of nausea and vomiting occured, and in another case a slight elevation of total billirubin level was noted.