Abstract
It is known that IgE receptors are divided into FcεRI and FcεRII. In particular, FcεRII receptor is a low affinity receptor and proteolysis on the surface of the inflammatory cell cleavages the FcεRII and releases soluble CD23 into the circulating blood. On the other hand, ketotifen (Zaditen(R)), an antiallergic drug with an inhibitory activity for platelet-activating factor inhibited the development of IgE receptor. In this paper, we estimated the level of soluble CD23 in the serum of patients with nasal allergy during the administration of ketotifen and studied the relationship between the change of CD23 and its parameters on nasal allergy. In the present study the results were as follows:
1) The soluble CD23 level in the serum of patients with a nasal allergy increased significantly (p<0.001) before the administration of ketotifen, compared to that in healthy adults.
2) Differences of soluble CD23 concentration before and after the administration of ketotifen showed a reverse correlation and also correlated significantly with the eosinophil count (p<0.05 r=-0.43). From the above-mentioned results, it was suggested that a decrease of eosinophil, bearing CD23 cells, caused an increase in the amount of soluble CD23 in the circulating blood after the administration of ketotifen.
