Abstract
The purpose of this study was to investigate whether or not amidotrizoate (ATZ) combines with positive charged marginal cells in the stria vascularis. We presume that ATZ acts as a barrier in combination with pathological endothelial cells which demonstrate positive charges in sudden deafness. ATZ was perfused into the cochlea duct in guinea pigs anesthetized with ketamine/xylazine. After 1% silver lactate made ATZ insoluable with 6 fixations, AG-particles in the tissue were observed by an electron microscope and then were compaired between ATZ group and control group. The Ag-particles were not observed to specificaly be combined with the endolymphatic surface of the marginal cells in any fixations. The number of Ag-particles in the strial component cells in the ATZ group were more than those in the control group after one fixation. These findings thus suggested that the combination of ATZ and marginal cells might not be strong enough and, as a restlt, ATZ might thus invade the stria vascularis.
