Abstract
We studied fleroxacin for its utility in four patients with chronic sinusitis at sinectomy. After the oral administration of 300mg of fleroxacin, the serum and maxillary sinus concentrations were determined. The mean serum concentration was 2, 56μg/ml at 2 hours after administration, 1-69μg/ml at 6 hours after administration, and 0.78μg/ml at 24 hours after administration. The mean concentration of maxillary sinus mucosa was 2.99μg/g. Based on the above results, fleroxacin is thus considered to be rapidly absorbed after oral administration and is also well distributed into the maxillary sinus mucosa. lts clinical efficacy was also found to be good in all four patients and no side effects were observed in any of the patients. We therefore considered fleroxacin to be a safe and useful drug for chronic sinusitis at operation.
