Abstract
Clinical studies were carried out to evaluate the effectiveness and safety of clarithromycin (CAM) for the treatment of otitis media in children. The results were as follows: CAM was orally administered to 86 pediatric patients. The clinical efficacy rates, evaluated in 71 patients, were 88.7%. The bacteriological eradication rates were 94.1% for monobacterial infections caused by gram-positive organisms, 75.0% for monobacterial infections caused by gram-negative organisms, and 100% for polybacterial infections, while the overall eradication rate was 90.0%. Side effects were observed in 3 of 80 patients, while clinical abnormalities were observed in 3 of 39 patients who underwent clinical laboratory tests both before and after treatment. Based on the above results, CAM is therefore considered to be highly effective as a treatment of otitis media in children.
