Abstract
We herein report a case of Collet et Sicard syndrome due to a fungal infection associated with MPO-ANCA-related microscopic polyangitis (MPA). The patient was a 71-year-old male who was diagnosed to have MPA at another hospital in 2003 and for which he received medical treatment. In addition, he has also been suffering from coughing and a low-grade fever since the beginning of 2003 and was therefore introduced to our hospital. He received steroid treatment after the diagnosis of Collet et Sicard syndrome was made, and his symptoms and the laboratory findings thereafter immediately improved. He complained of dysphasia and hoarseness since the beginning of 2004 and thus was introduced to our department. Repeated neurological examinations revealed lesions in cranial nerves IX, X, XI, and XII on the right side. A histological examination failed to reveal either any neoplasm or a fungal infection, however, a fungal infection was still highly suspected. As a result, we administered anti-fungal drugs to him and thereafter his neurologic symptoms dramatically disappeared. The importance of assuming the presence of a fungal infection in any cases of compromised host therefore cannot be overemphasized.
