Abstract
Complications of squamous cell carcinoma and leiomyosarcoma, as well as the occurrence of leiomyosarcoma alone in the larynx are very rare. We herein report two cases that showed an asynchronous growth of these tumors in the larynx. Case 1 demonstrated leiomyosarcoma first and thereafter developed squamous cell carcinoma. Case 2 first displayed squamous cell carcinoma and was treated by irradiation, then he later demonstrated leiomyosarcoma, which thus was initially considered to be associated with the previous radiation treatment, however, this possibility was later ruled out because of the short duration between the irradiation treatment and the appearance of the second tumor. An accurate diagnosis of laryngeal leiomyosarcoma is often hard to make because of the difficulty in making probes or performing histopathological examinations, and this disease is usually resistant to both chemotherapy and radiotherapy, while also demonstrating distant metastasis. It is therefore recommended that leiomyosarcoma in the larynx should be quickly diagnosed and treated by surgery while carefully distinguishing it from squamous cell carcinoma which is sensitive to irradiation in strong contrast to the radio-resistant character of leiomyosarcoma.
