Abstract
Carbohydrate as well as oxygen is most deeply concerned with the metabolism of the inner ear as energy sources of the nerve tissues.
The author formerly investigated the changes in phosphatase acting on adenosine triphosphate (A. T. P.) and diphosphopyridine nucleotide, high energy substances participating in carbohydrate metabolism, by staining the phosphatase in the cochlea of the irner ear of the guinea-pig exposed to white noise.
The authors reported here the effects of diphosphopyridine nucleotide on the animals injected with dihydrostreptomycin and on the patients of inner ear diseases.
(1) The authors could prevent to some extent by the administration of D. P. N. the decrease of the activity of alkali phosphatase observable in the sensory cells of the cochlea of the guinea- pig injected with dihydrostreptomycin.
2) The authors used 30-50mg of D.P.N. singly, or together with 30-50mg of A. T. P. or 30-50mg of V.B1 on 34 cases of inner ear diseases, and obtained favorable results on half of them.
