2017 Volume 120 Issue 10 Pages 1246-1250
Giant cell tumor of the bone (GCTB) is a rare osteolytic tumor accounting for 3-5% of all bone tumors and is characterized by aggressive growth, local recurrence, and lung metastasis, although it is classified as a benign tumor. Here, we report a 15-year-old male with GCTB of the sphenoidal bone. No symptoms were apparent at the time of the discovery of the GCTB. However, abducens nerve palsy was subsequently observed. After the first operation, a broad tumor reccured, so anti-RANKL (denosumab) was administered after the second surgery. As a result, the tumor was decreased in size, and the abducens nerve palsy disappeared. This outcome suggests that denosumab treatment might be effective for controlling GCTB in the head and neck region.
