Nippon Jibiinkoka Gakkai Kaiho
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
Original article
Giant Cell Tumor of the Sphenoid Bone controlled by Postoperative Denosumab Therapy
Tamami MatsumotoYoshihisa NakamuraMotohiko SuzukiMotoki TanikawaMitsuhito MaseShingo Murakami
Author information
JOURNAL FREE ACCESS

2017 Volume 120 Issue 10 Pages 1246-1250

Details
Abstract

 Giant cell tumor of the bone (GCTB) is a rare osteolytic tumor accounting for 3-5% of all bone tumors and is characterized by aggressive growth, local recurrence, and lung metastasis, although it is classified as a benign tumor. Here, we report a 15-year-old male with GCTB of the sphenoidal bone. No symptoms were apparent at the time of the discovery of the GCTB. However, abducens nerve palsy was subsequently observed. After the first operation, a broad tumor reccured, so anti-RANKL (denosumab) was administered after the second surgery. As a result, the tumor was decreased in size, and the abducens nerve palsy disappeared. This outcome suggests that denosumab treatment might be effective for controlling GCTB in the head and neck region.

Content from these authors
© 2017 The Oto-Rhino-Laryngological Society of Japan, Inc.
Previous article Next article
feedback
Top