Abstract
Based upon my statistical observations in the past on various cases of acute otitis media, I have been able to confirm that penicillin has had marked effect upon the improvement of prognosis of the disease and the prevention of its complications. Therefore I have further made experimental studies about the extent of the preventive effect which penicillin might have on the post-operative labyrinthitis following to the fenestration operation of labyrinth. The fenestration of the labyrinth have been performed on 40 rabbits. On one-half of these rabbits, 300, 000 units of penicillin sol were injected into the muscules every day for one month, while the other half were left untreated. All these rabbitis were fed for one month and observ- ations were made. Then histological specimens were obtained from their labyrinths, and histo- pathological examinations were carried out. As for the reaction of the living rabbits during the time of the treatment after the operation, the rabbits which were treated by penicillin injection showed the less severe symptoms of labyr- inthitis than those which were not treated. Histologicaly, while the former showed serous labyrinthitis, the latter showed purulent labyrinthitis. The series of experiments above mentioned show that penicillin has a preventive effect in certain degrees on the post-operative labyrinthitis.
