A STUDY ON THE MECHANISM OF PHLEBOID OLFACTORY FUNCTION

EIKO OKABE

doi:10.3950/jibiinkoka.92.111

EIKO OKABE

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JOURNAL FREE ACCESS

1989 Volume 92 Issue 1 Pages 111-120

DOI https://doi.org/10.3950/jibiinkoka.92.111

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Published: January 20, 1989 Received: - Available on J-STAGE: March 19, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 19, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Department of Otorhinolaryngology, School of Medicine, Showa University, Tokyo Phieboid olfactory test has wide clinical application for olfactory disturbance. Many unclarified aspects still remain concerning the mechanism of smell after an intravenous infusion of Alinamin^®.It is believed that when Alinamin^® is infused intravenously and biproducts are discharged from the blood into the alveoli, odorous substances reach the nasal cavity through exhalation.In order to clarify the mechanism of smell in more detail, we conducted the following experiments : 1) Cases of laryngectomy were examined to determine if intravenous infusion of Alinamin^® affected the olfactory organ.2) Saliva specimens in healthy subjects were collected before and after intravenous infusion of Alinamin^® and examined for the presence of a secreted odorous substance using a functional test.3) Healthy subjects who were inhibited in their sense of smell were examined for the presence of garlic odor after intravenous infusion of Alinamin(R'. The results were as follows : 1) 80% of subjects of laryngectomy without cotton in the nares and 20% of subjects of laryngectomy with cotton in the nares perceived the garlic odor. 2) Garlic odorous substance was not recognized in saliva specimens collected before and after intravenous infusion of Alinamin^®. 3) The healthy subjects inhibited in their sense of smell and intravenously infused with Alinamin^® perceived the odor at the same time as exhalation. The above results indicated that the mechanism of smell after intravenous infusion of Alinamin^® occurred via exhalation, but not through the other routes.
Right : Phieboid olfactory test has wide clinical application for olfactory disturbance.
Many unclarified aspects still remain concerning the mechanism of smell after an intravenous infusion of Alinamin®.It is believed that when Alinamin® is infused intravenously and biproducts are discharged from the blood into the alveoli, odorous substances reach the nasal cavity through exhalation. In order to clarify the mechanism of smell in more detail, we conducted the following experiments : 1) Cases of laryngectomy were examined to determine if intravenous infusion of Alinamin® affected the olfactory organ. 2) Saliva specimens in healthy subjects were collected before and after intravenous infusion of Alinamin® and examined for the presence of a secreted odorous substance using a functional test. 3) Healthy subjects who were inhibited in their sense of smell were examined for the presence of garlic odor after intravenous infusion of Alinamin®.
The results were as follows:
1) 80% of subjects of laryngectomy without cotton in the nares and 20% of subjects of laryngectomy with cotton in the nares perceived the garlic odor.
2) Garlic odorous substance was not recognized in saliva specimens collected before and after intravenous infusion of Alinamin®.
3) The healthy subjects inhibited in their sense of smell and intravenously infused with Alinamin® perceived the odor at the same time as exhalation.
The above results indicated that the mechanism of smell after intravenous infusion of Alinamin® occurred via exhalation, but not through the other routes.

Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Phieboid olfactory test has wide clinical application for olfactory disturbance.
Many unclarified aspects still remain concerning the mechanism of smell after an intravenous infusion of Alinamin®.It is believed that when Alinamin® is infused intravenously and biproducts are discharged from the blood into the alveoli, odorous substances reach the nasal cavity through exhalation. In order to clarify the mechanism of smell in more detail, we conducted the following experiments : 1) Cases of laryngectomy were examined to determine if intravenous infusion of Alinamin® affected the olfactory organ. 2) Saliva specimens in healthy subjects were collected before and after intravenous infusion of Alinamin® and examined for the presence of a secreted odorous substance using a functional test. 3) Healthy subjects who were inhibited in their sense of smell were examined for the presence of garlic odor after intravenous infusion of Alinamin®.
The results were as follows:
1) 80% of subjects of laryngectomy without cotton in the nares and 20% of subjects of laryngectomy with cotton in the nares perceived the garlic odor.
2) Garlic odorous substance was not recognized in saliva specimens collected before and after intravenous infusion of Alinamin®.
3) The healthy subjects inhibited in their sense of smell and intravenously infused with Alinamin® perceived the odor at the same time as exhalation.
The above results indicated that the mechanism of smell after intravenous infusion of Alinamin® occurred via exhalation, but not through the other routes.

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