MECHANISMS OF DEVELOPMENT OF ENDOLYMPHATIC HYDROPS FOLLOWING SECONDARY IMMUNE RESPONSE IN THE ENDOLYMPHATIC SAC OF GUINEA PIGS

TOMIYAMA SHUN-ICH

doi:10.3950/jibiinkoka.94.12_1844

TOMIYAMA SHUN-ICH

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JOURNAL FREE ACCESS

1991 Volume 94 Issue 12 Pages 1844-1852

DOI https://doi.org/10.3950/jibiinkoka.94.12_1844

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Published: December 20, 1991 Received: - Available on J-STAGE: March 19, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 19, 2008 Reason for correction: - Correction: CITATION Details: [in Japanese]

Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 19, 2008 Reason for correction: - Correction: CITATION Details: Wrong : 2) Hallpike CS, Cairns H : Observations on the pathol-ogy of Meniere's syndrome. J Laryngol 53: 626-655, 1938.
3) Guild SR: The circulation of the endolymph. AmJ Anat 39: 57-81, 1927.
4) Lundquist PG, Kimura RS, Wersall J : Ultras-tructual organization of the epithelial lining in theendolymphatic duct and sac in the guinea pig.Acta Otolaryngol (Stockh) 57: 65-80, 1964.
5) Lim D, Silver P : The endolymphatic duct system.A light and electron microscopic investigation.In : Proc Barany Society Meeting. Pulec J, ed. LosAngeles : 390, 1974.
6) Wackym PA, Friberg U, Linthicum FH et al:Human endolymphatic sac : Morphologic evidenceof immunologic function. Ann Otol Rhinos Laryn-gol 96: 276-81, 1987.
7) Takahashi M, Harris JP : Anatomic distributionand localization of immunocompetent cells in nor-mal mouse endolymphatic sac. Acta Otolaryngol(Stockh) 106: 409-416, 1989.
8) Rask-Andersen H, Stahle J : Immunodefense of theinner ear ? Lymphocytemacrophage interaction inthe endolymphatic sac. Acta Otolaryngol (Stock.h) 89: 283-294, 1980.
9) Arnold W, Altermatt HJ, Grebbers JO : Demonstra-tion of immunoglobulin (SIgA, IgG) in the humanendolymphatic sac. Laryngol Rhinol Otol 63: 464-467, 1984.
10) Tomiyama S, Harris JP: The endolymphatic sac.its importance of inner ear immune response.Laryngoscope 96: 685-691, 1986.
11) Takahashi M, Harris JP: Analysis of im-munocompetent cells following inner ear immunos-timulation. Laryngoscope 98: 1133-1138, 1988.
12) Tomiyama S : The immuno-function of the en-dolymphatic sac in the inner ear immune responseand endolymphatic hydrops following endolym-phatic sac immune response. Otol Jpn 1 suppl (1)31-39, 1991.
14) Tomiyama S, Harris JP: Elevation of inner earantibody following direct antigen challenge of theendolymphatic sac. Acta Otolaryngol (Stockh)107: 202-209, 1989.
15) Arenberg IK, Marovitz WF, Shambaugh GE: Therole of the endolymphatic sac in pathogenesis ofendolymphatic hydrops in man. Acta Otolaryngolsuppl 275: 1970.

Right : 2) Hallpike CS, Cairns H : Observations on the pathol-ogy of Meniere's syndrome. J Laryngol 53: 626-655, 1938.
3) Guild SR: The circulation of the endolymph. AmJ Anat 39: 57-81, 1927.
4) Lundquist PG, Kimura RS, Wersall J : Ultras-tructual organization of the epithelial lining in theendolymphatic duct and sac in the guinea pig.Acta Otolaryngol (Stockh) 57: 65-80, 1964.
5) Lim D, Silver P : The endolymphatic duct system.A light and electron microscopic investigation.In : Proc Barany Society Meeting. Pulec J, ed. LosAngeles : 390, 1974.
6) Wackym PA, Friberg U, Linthicum FH et al:Human endolymphatic sac : Morphologic evidenceof immunologic function. Ann Otol Rhinos Laryn-gol 96: 276-81, 1987.
7) Takahashi M, Harris JP : Anatomic distributionand localization of immunocompetent cells in nor-mal mouse endolymphatic sac. Acta Otolaryngol(Stockh) 106: 409-416, 1989.
8) Rask-Andersen H, Stahle J : Immunodefense of theinner ear ? Lymphocytemacrophage interaction inthe endolymphatic sac. Acta Otolaryngol (Stock.h) 89: 283-294, 1980.
9) Arnold W, Altermatt HJ, Grebbers JO : Demonstration of immunoglobulin (SIgA, IgG) in the humanendolymphatic sac. Laryngol Rhinol Otol 63: 464-467, 1984.
10) Tomiyama S, Harris JP: The endolymphatic sac.its importance of inner ear immune response.Laryngoscope 96: 685-691, 1986.
11) Takahashi M, Harris JP: Analysis of im-munocompetent cells following inner ear immunos-timulation. Laryngoscope 98: 1133-1138, 1988.
12) Tomiyama S : The immuno-function of the en-dolymphatic sac in the inner ear immune responseand endolymphatic hydrops following endolym-phatic sac immune response. Otol Jpn 1 suppl (1)31-39, 1991.
14) Tomiyama S, Harris JP: Elevation of inner earantibody following direct antigen challenge of theendolymphatic sac. Acta Otolaryngol (Stockh)107: 202-209, 1989.
15) Arenberg IK, Marovitz WF, Shambaugh GE: Therole of the endolymphatic sac in pathogenesis ofendolymphatic hydrops in man. Acta Otolaryngolsuppl 275: 1970.

Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Previously the author reported the immediate development of endolymphatic hydrops (e. hydrops) following direct challenge of secondary antigen to the endolymphatic sac (ES) in guinea pigs, during the early phases of postchallenge, ranging from 1 to 5 weeks.
The present study reports the results of specimens taken up to 10 weeks postchallenge, and correlation of e.hydrops to perilymph in antigenspecific antibody levels. From the present results, mechanisms of e.hydrops induced ES immune reaction are suggested as follows. 1) In the early stage of e.hydrops, an acute inflammatory reaction in the ES may produce endolymph by an increased vascular permeability of the inner ear and may impaire endolymph absorption from the ES. 2) In the latter stage of e.hydrops, the moderate cellular infiltration in the ES may cause chronic impairment of endolymph absorption in the ES.

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