Practica Oto-Rhino-Laryngologica
Online ISSN : 1884-4545
Print ISSN : 0032-6313
ISSN-L : 0032-6313
Original articles
Effects of an Anti-Histamine Drug on Prevention of Profound Sensorineural Hearing Loss after Otological Surgery
Takefumi KamakuraTadashi KitaharaKatsumi DoiHidenori Inohara
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2010 Volume 103 Issue 11 Pages 997-1001

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Abstract
A 36-year-old man who had undergone endolymphatic sac surgery suffered from sensorineural hearing loss in the same ear after breathing strongly through his nose and hearing a “pop”. Based on persistent dizzy spells and profound hearing loss, we made diagnosis of perilymphatic fistula and conducted exploratory tympanotomy. We closed the obvious round window fistula during surgery using fascia, reducing dizziness and sensorineural hearing loss.
To prevent perilymphatic fistula after otological surgery, we administered olopatadine 10 mg/day for 2 weeks just after surgery. In comparison to cases not given olopatadine, those given postoperative olopatadine showed an apparent decrease in the incidence of profound sensorineural hearing loss, probably due to perilymphatic fistula.
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© 2010 The Society of Practical Otolaryngology
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