A Case of Oral Squamous Cell Carcinoma with Chronic Mucosa Graft-Versus-Host Disease after Allogenic Bone Marrow Transplantation

Abstract

We report a case of lower gingiva squamous cell carcinoma (SCC) concomitant patient with chronic oral mucosa graft-versus-host disease (GVHD) after allogenic bone marrow transplantation (BMT).
A 57-year-old man seen in March 2009 for lower gingiva and tongue SCC. He had had chronic myelocytic leukemia (CML) in 1989, chronic GVHD arising in allogenic BMT in 1898 and tongue SCC in 2005. He underwent surgical resection, neck dissection, and mandible reconstruction in April 2009. He remains free of cancer but suffers from chronic oral mucosa GVHD. Chronic GVHD has been reported associated with secondary malignancy risk following allogeneic BMT, indicating the careful oral cavity observation needed in those with chronic oral mucosa GVHD.