A Case of Small Cell Carcinoma of the Paranasal Cavity Treated with Chemoradiotherapy

Abstract

There are few reports of small cell carcinoma originating in the nasal and paranasal cavity, but in this paper, we report on a case we experienced, in which small cell carcinoma developed around the ethmoidal sinus.
A 57-year-old male with the major complaint of a left nasal obstruction and epistaxis consulted with his local doctor, and because a hemorrhagic mass filling the nasal cavity was observed, he was referred to our department. CT imaging showed a tumorous lesion was seen accompanying a contrast effect from within the anterior cranium to the nasal cavity. As a result of the biopsy, small cell carcinoma of the nasal cavity (T4bN0M0) was diagnosed, and treatment commenced.
We believed that it was impossible to avoid bilateral visual organ disorder, and after chemotherapy using irinotecan and cisplatin radiotherapy was concomitantly administered only after the tumor had shrunk.
In the imaging after treatment, because there was a possibility of there being some residual tumor, a PR (partial response) was determined, and for the purpose of evaluation, navigation accompanying an endoscopic biopsy was performed. For the right calcified portion, there were findings only of growth of fragmentary bone tissue, granulation tissue and blood vessels, and there were no obvious malignant findings, so from the above, the treatment results were judged to be pathological CR (complete response).