Practica Oto-Rhino-Laryngologica
Online ISSN : 1884-4545
Print ISSN : 0032-6313
ISSN-L : 0032-6313
Original articles
A Case of Steroid-resistant Kimura Disease Successfully Treated by Radiotherapy
Yuki YamaguchiTsuyoshi UmeharaKatsuyoshi SuzukiHaruki KondoJunya KitaArika MatsushitaKosuke Sugawara
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2019 Volume 112 Issue 2 Pages 127-133

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Abstract

Kimura disease (soft eosinophilic granulomatosis) is a chronic inflammatory granulomatous condition characterized by eosinophilic infiltration of the soft tissues. We treated a 40-year-old male patient with steroid-resistant Kimura disease on the left side of the neck by radiotherapy. The patient presented with a mass in the left side of the neck that he had first noticed 5 years earlier. He had received steroid therapy, but developed recurrent disease and was judged as being resistant to steroid therapy. The lesion was irradiated with 30 Gy, in five-weekly fractions of 2 Gy. After radiotherapy, complete remission of the lesion was observed, with improvements in both the peripheral blood eosinophil count and the serum IgE level. Neither lesion recurrence, nor delayed complications were detected up to 5 years after the radiotherapy. This case indicates that radiotherapy is an effective treatment option for Kimura disease. However, careful follow-up and informed consent for the treatment are necessary.

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© 2019 The Society of Practical Otolaryngology
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