Abstract
The ideal conditions for tympanic membrane perforation (TMP) closure by outpatient treatment include technical simplicity, low invasiveness, high perforation closure rate, a high safety margin and the use of economically viable materials. Platelet-rich plasma (PRP), which contains growth factors such as platelet-derived growth factor, transforming growth factor-beta and insulin-like growth factor I, induces regeneration in various tissues to promote excellent wound-healing effects. As PRP is an autohemic substance, it is non-toxic, non-immunoactivating and indicates a high safety margin in application. The present study developed a TMP closure method using autologous PRP combined with an atelocollagen membrane (CM). Of the 25 TMP ears who underwent surgical trimming of tissues around the TMP under local anesthesia, the tympanic membrane was patched with PRP-infiltrated CM preparations. In the present study, the TMP closure rate was improved to 88%. The findings in our study suggest that TMP closure with the PRP/CM patching method yields excellent rates with a high safety margin, the novel approach shows limited invasiveness, and requires simple technical skills.
