2008 Volume 101 Issue 12 Pages 943-949
Basaloid squamous cell carcinoma (BSCC) is a histologically distinctive variant of squamous cell carcinoma that was first reported by Wain in 1986. BSCC has been reported to be biologically aggressive and carries a poor prognosis because of frequent lymph node and distant metastases. We report here in two cases of basaloid squamous cell carcinoma.
The first patient was a 72-year-old male, who presented with masses on the oral floor and in the left neck. The tumor was treated superselective intra-arterial infusion chemotherapy combined with radiation therapy. The patient is currently alive without tumor growth 11 months after the treatment. The second patient was an 54-year-old female, who presented with masses in the oropharynx and in the left neck. Superselective intra-arterial infusion chemotherapy combined with radiation therapy was also performed in this case. The patient is also currently alive without tumor growth 10 months after the treatment. In both cases, the characteristic microscopic features of BSCC were observed, which are comedo necrosis and peripheral palisading. Superselective intra-arterial infusion chemotherapy combined with radiation therapy was very valuable to promoto the quality of life of these patients.
