Abstract
Observation of 36 laryngeal cancer patients was made with respect to a set of immunological parameters in the periods before and after treatment, including long-term follow up. Several trends observed in this series were as follows: 1) In the pretreatment group, T-cell %, lymphocyte blastoid reaction (PHA, Con. A) and skin reaction (PHA, PPD) were generally kept in the normal ranges; however, T-cell count and lymphocyte count were reduced in a great portion of the patients. 2) In the no recurrence group, T-cell count, lymphocyte count, IgG-FcR/T-cell (Tγ) and skin reaction were normal in many cases. The recurrence group showed decrease in T-cell %, T-cell count and lymphocyte count. 3) When the data were compared before and after surgery, T-cell count, lymphocyte count and PPD skin reaction were found to increase after surgery in some cases. In a few cases, however, reduction was noted in T-cell %, B-cell %, lymphocyte count and skin reaction for a long time after surgery. 4) Radiation therapy did not seem to induce substantial effects in T-cell % and skin reaction.
