The Experimental Results of Endolymphatic Sac Obliteration at Osaka University with Regard to the Functional Tests in Guinea Pigs after Obliteration of the Endolymphatic Sac

Abstract

Several experiments were reported with regard to the experimental endolymphatic hydrops of guinea pigs after obliteration of the endolymphatic sac.
1. Uno (1969) reported that the cochlear potentials of guinea pigs with endolymphatic hydrops were depressed to a maximum amplitude of CM and the N₁ amplitude of AP was decreased.
2. Tomiyama (1969) and the present authors reported the increase in the directional preponderance differences of C & E DPRT in the guinea pigs after obliteration of the endolymphatic sac.
3. The guinea pigs with experimental endolymphatic hydrops produced positive results to the experimental furosemide test by C & E DPRT, and the histology of the inner ears of guinea pigs with the positive furosemide test revealed either normalizing or collapsing of the endolymphatic hydrops which had once been produced in the affected ear, while the opposite ear was almost normal.