1983 Volume 76 Issue 11 Pages 3007-3014
CMX Otic Solution, an antibiotic preparation developed for topical application, was tested for its clinical efficacy and antibacterial activity in patients with external otitis and chronic otitis media. 1% CMX or 0.5% CMX, the pH of which was adjusted to 6.5, was applied to the external auditory meatus or tympanum for 10 minutes, twice a day.
The effectiveness rate of 1% CMX was 88.2% and that of 0.5% CMX was 65.4%. In 94.1% of patients receiving 1% CMX and in 65.4% of those receiving 0.5% CMX culture became negative. 1% CMX was significantly superior to 0.5% CMX against Staphylococcus aureus and Pseudomonas aeruginosa. No serious side effects were observed. When 1% CMX was applied to the tympanum, the concentration of CMX in the serum 30 minutes later was 0.0125-0.02μg/ml.
Topical 1% CMX Otic Solution is effective in the treatment of chronic otitis media and external otitis. Patients should be tested for hypersensitivity before administration of this preparation.
