Abstract
A study was made of the penetration of Bacampicillin (BAPC) into the tonsillar tissue of 20 patients treated by tonsillectomy for chronic tonsillitis. And bacteria in throat cultures of out-patients were tested for sensitivity to Ampicillin (ABPC).
1. ABPC concentration in the tonsil was determined in 20 cases of tonsillectomy after BAPC administration. Good tissue penetration was found, with peak concentration 2 to 3 hours after administration.
2. When BAPC was administered to 9 patients with acute tonsillitis, the results were excellent in 2, good in 6, and poor in 1 (88.9% improvement).
3. Throat cultures showed that many bacteria, such as β-streptococcus, S. pyogenes, S. faecalis and H. influenzae, were very sensitive to ABPC.
These results indicate that BAPC is useful in the treatment of bacterial throat infections
