Abstract
The blood flow in the scala media of guinea pigs with hydrops was measured by the hydrogen clearance method during the administration of eperisone hydrochloride, betahistine mesylate or glycerol and during endolymphatic sac surgery, after a preliminary examination had determined which condition was suitable.
1) It was found that oral administration could be used in this examination.
2) The effects of the drugs were evaluated by comparing in treated and untreated animals.
3) During eperisone hydrochloride administration, the blood flow in the scala media was 9.0±0.7ml/min/100g (n=4).
4) With betahistine mesylate, it was 8.1±1.0ml/min/l00g (n=4)
5) With glycerol, it was 5.6±1.2 ml/min/100g (n=4).
6) During endolymphatic sac operation, the blood flow was 6.6±1.3ml/min/100g (n=4).
7) Statistical analysis showed a significant increase of blood flow in the scala media in animals receiving eperisone hydrochloride or betahistine mesylate, but no significant difference in the glycerol or endolymphatic sac operation.
