Abstract
Forty seven patients with tinnitus were given sodium valproate (400mg orally twice a day) after evaluating the effect of intravenous lidocaine (40-60mg). With lidocaine injection, 19 of 47 patients had complete relief from tinnitus, 19 had partial relief (over 30%), and 9 had no relief Of 38 patients who took sodium valproate over two weeks, one patients had excellent relief (over 80% disappearance of tinnitus by subjective evaluation), 8 had good relief (50-80% disappearance), 16 had partial relief (20-50% disappearance), and 13 had no relief. The effect of sodium valproate correlated with the effect of lidocaine and serum level of sodium valproate. It was considered that the efficacy of sodium valproate would increase when used in combined therapy with other drugs or therapies.
