Abstract
The clinical effects of tizanidine hydrochloride on tinnitus were investigated in 41 patients (60 ears).
1. “Slight improvement, ” “moderate improvement, ” or “great improvement” was reported for 75% of the 60 ears.
2. The agent was more effective in females than in males. The type of tinnitus most effectively treated was that associated with sensorineural hearing loss of unknown etiology.
3. Patients with a tinnitus history off under 5 years, with pure tone tinnitus, or high pitch tinnitus responded best.
4. Tinnitus with hearing loss of less than 40dB was more responsive to the agent than that with hearing loss of more than 40dB.
5. Patients were given 1mg, 2mg, or 3mg per day. The 3mg per day group showed the best improvement.
6. The agent proved effective in a majority of patients who did not respond to eperisone hydrochloride treatment.
7. Shoulder stiffness was reduced in 50% of the patients and headache or head dullness in 75% with these complaints.
8. Side effects were noted in 3 patients (7.3%).
