1992 Volume 85 Issue 12 Pages 1991-1995
The efficacy of tranilast, an antiallergy agent, in treating otitis media with effusion (OME) was examined by analyzing its effect on prostaglandin synthesis. In 54 patients with OME (54 ears), tranilast was administered for 14 days after elimination of middle ear effusion with tympanotomy. Forty-four ears showed no recurrence of effusion after tranilast therapy, while 10 ears developed effusion again. In these 10 ears, the levels of two prostaglandins (TXB2 and PGD2) in middle ear effusion were higher after tranilast therapy than before tranilast therapy, which suggested that prostaglandins are associated with intractable OME. The administered tranilast was transferred into the middle ear effusion effectively.
