Intratumor Injection of OK-432/Fibrinogen for Head and Neck Carcinomas

Abstract

We studied the antitumor effect of intratumoral injections of OK-432 mixed with fibrinogen, including factor-XIII, and 1ml of aprotinin on head and neck carcinoma. Out of 10 patients, macroscopic evidences of reduction of tumor size were observed in two cases. The other 8 showed histopatholgical degeneration of tumor cells and marked infiltration of inflammatory cells in the area of injection. These findings suggest that OK-432 in conjunction with fibrinogen solution may play a role in the immunotherapy of head and neck carcinoma.