Abstract
Aspirin-induced Asthma (AIA) is characterized by three clinical findings; asthma, aspirin intolerance and nasal polyps. We reported the outcome of endoscopic sinus surgery (ESS) in 12 patients with AIA, and compared the number of eosinophils in paraffin sections of nasal polyps between AIA and non-AIA patients. All ESSs were safely performed using drip injection of steroids and local anesthesia with 2% pure Xylocaine® during surgery. They improved asthma and nasal symptoms in all patients. Eosinophils in nasal polyps from AIA patients were significantly more abundant than those in nasal polyps of non-AIA patients (p<0.01). AIA-patients showed significantly more peripheral blood eosinophils than non-AIA patients (p<0.05). The role of eosinophils in nasal polyps of AIA and surgical notes for treatment of AIA were discussed.
