Abstract
Twenty one patients with otomycosis were treated with oral Itraconazole tablets. The patients were given 50mg or 100mg of Itraconazole per day until clinical symptoms improved. The overall effectiveness rates were 42.9% (9/21) with excellent efficacy, 38.1% (8/21) with good efficacy, 4.8% (1/21) with no efficacy respectively. The fungus culture tests were negative in 8 patients among the 15 who underwent fungus culture tests after treatment. A sufficient amount of Itraconazole to be therapeutic was detected in the cerumen of one patient (118.81ng/gr. after 2 weeks administration, and 453.56ng/gr. after 4 weeks administration, respectively), and concentrations exceeded most of MIC (0.063-1μg/ml). An adverse reaction was experienced by only one patient, a 59 y. o. male, who suffered from diarrhea. Abnormal laboratory data were found in a 73 y. o. male, among the 11 patients who underwent blood tests both before and after the treatment, showing minor elevation of GOT and GPT. These observations suggest that Itraconazole is a safe and useful oral medicine for treatment of otomycosis.
