Abstract
The aim of this study was to investigate the efficacy of suplatast tosilate prescribed before the pollen season and during the pollen season. Suplatast tosilate, 300mg/day, was prescribed for 10 patients before the start of the pollen season and for 6 patients during the pollen season. Patients kept a diary of nasal symptoms.
Based on the nasal symptom diaries a nasal symptom score was prepared. The rate of improvement was 70% with preseasonal administration and 33% with administration after pollen scattering.
Pollen levels showed three peaks (3/5, 3/14, 3/29) during the pollen season in 1998, and in the preseasonal administration, the symptoms were suppressed at these three peakses pecially at third peak in 70% of patients.
In the administration during pollen season, the symptom score was high at second and third peaks in the noneffective patient, but the symptoms were suppressed at the second and third peaks in the effective patients.
Based on these findings we suggest that suplatast tosilate should be administered more than one month before the first peak in pollen levels.
