Abstract
Salivary duct carcinoma (SDC) is a high-grade aggressive malignancy of the salivary gland, that was first described by Kleinsasser et al. in 1968. We report here two cases of salivary duct carcinoma in the parotid gland. The first patient was a 64-year-old male, who presented with a mass in the right parotid region. The tumor in the parotid gland was treated using en bloc resection with modified neck dissection and postoperative radiation therapy was performed. The patient is alive without recurrence for three years postoperatively. The second patient was an 80-year-old male, who presented with a bulky mass in the right parotid region. In this case, en bloc resection with cutaneous reconstruction with a pectoralis major musculocutaneous flap was performed. The patient is also alive wtihout recurrence at one year postoperatively. In both cases, the characteristic microscopic features of SDC were observed, which are comedo necrosis and the cribriform pattern of intraductal growth. An en bloc resection in combination with adjuvant radiotherapy is currently the principal treatment for SDC, but in the future other alternative therapeutic modalities, such as the hormonal therapy used in prostatic carcinoma, should be considered.
