Abstract
Gastroesophageal reflux disease (GERD) which includes otorhinolaryngologic symptoms is called laryngopharyngeal reflux disease (LPRD). GERD shows a high incidence in progressive systemic sclerosis (PSS) and mixed connective tissue disease (MCTD).
Two cases of LPRD with collagen disease, MCTD and PSS, are reported. The chief complaints were globus sensation and hoarseness. Arytenoid swelling, vocal cord edema and interarytenoid pachydermia were found by laryngeal fiberscopy. The clinical symptoms and findings disappeared after administration of proton pump inhibitor (PPI).
