A Case of Submandibular Squamous Cell Carcinoma Producing Granulocyte-colony Stimulating Factor

Abstract

Squamous cell carcinoma of the submandibular gland is an extremely rare salivary gland cancer ranging from 0.015 to 0.045 percent of all head and neck cancers, and is associeted with a poor prognosis. Granulocyte-colony stimulating factor (G-CSF) producing tumors also have a poor prognosis. This type of tumor produces G-CSF itself, which promotes tumor growth, thereby potentially accelerate the clinical progression of the disease through an additional synergic effect. The present study describes our experience in treating a 59-year-old male patient who was thought to have a G-CSF-producing squamous cell carcinoma of the submandibular gland.