Meniere's Disease and Coenzyme Q10 (1)
1986 Volume 1986 Issue Supplement8 Pages 249-255
Details
1986 Volume 1986 Issue Supplement8 Pages 249-255
Coenzyme Q10 (Co Q10) is a quinone of the mitochondrial electron-transfer system that plays an important role in energy-producing process of the tissue metabolism. Therefore, the deficiency of Co Q10 is likely to cause serious dysfunction for the vestibular system that is in action continuously as is the myocardium.
On the viewpoint, the serum Co Q10 assayed quantita t i vely by High Performance Liquid Chromatography (HPLC) in 30 cases of Meniere's disease.
In spite of the Co Q10 level is said to be extremely hig h in cases of hyperlipemia, it remained at the upper limit of the normal range (0.84±0.2 μg/ml) in 5 out of 8 cases of Meniere's disease complicated with hyperlipemia, evidently low at 0.65±0.16 in 22 cases without hyperlipemia and extremely low at 0.40±0.04 in 5 cases having an orthostatic decrease in the hight of the T11 wave in ECG.
Findings above have led us to conclude that the Co Q10 levels in patients with Meniere's disease are low and have something to do with development of the disease and to confirm the value of follow-up investigations.
