1987 Volume 1987 Issue Supplement10 Pages 25-29
The influence of Fosfomycin (FOM) against the antitumor effect of Cisplatin (CDDP) was investigated using ddY-strain mice. Each mouse was inoculated with Ehrlich carcinoma cells (2×106cells/0.2 ml) subcutaneously. One group was given daily doses of 1.0,1.5 or 2.0 mg/kg/day of CDDP for 5 consecutive days, and the other one was given 5.0,7.5 or 10.0 mg/kg of CDDP for only one day. Both groups were treated with or without 300 mg/kg/day of FOM for consecutive 5 days. The tumors were weighed on day 14.
There was no diffe r ence of the tumor weight between the group of CDDP alone and the one in combination with FOM. It is concluded that this combined administration does not influence the antitumor effect of CDDP.
