The Role of Aldosterone in the Endolymphatic Sac

Abstract

To assess the role of aldosterone in the endolymphatic sac, the effect of aldosterone and its antagonist on the endolymphatic sac, the DC potential (ESP) was examined in the guinea pig. The extrinsic aldosterone (1 mg/kg, i. v. ) induced no change in the ESP for 1 hr after the administration. However, canrenoate, an aldosterone antagonist produced a dose-dependent decrease in the ESP. Pretreatment of extrinsic aldosterone attenuated the ESP change by canrenoate. Therefore aldsterone may play an important role in the function of the endolymphatic sac.