The Prediction of the Effect for Anti-Allergic Drugs by Nasal Provocation Test

Abstract

We performed the nasal provocation test before and after anti-allergic treatment for the patients with a nasal allergy.
1. There were n o relationships between the degree of improvement obtained by antiallergic drugs and the severities of allergic symptoms nor the degree of nasal responses to the antigen provocation before the treatment.
2. The relationship betwee n the response in the nasal provocation test and the clinical symptoms was significant. The resting nasal airway resistance (NAR) reflected the clinical nasal obstruction score more than the percent changes in NAR after the provocation.
3. Prediction of estimation for recurrence w a s not possible by clinical symptoms nor by the responses to the antigen provocation at the time of ceasation of drug administration.
The group with a higher improvement rate in the provocation test t e nded to be in longer remission.
We reconfirmed that the nasal provocation test was useful for the objective assessment of clinical symptoms. Moreover, the nasal provocation test may be useful in predicting the remission period following the ceasation of drug administration.