Critical Studies of Emedastine Difumarate for Japanese Cedar Pollinosis in the First Burst of Grain

Abstract

In patients with Japanese cedar pollinosis, clinical efficacy of emedastine difumarate (DAREN)was studied. Fifty-four cases received 4 mg/day for at least 2 weeks during the initial period of pollen season. Compared with patients who received no treatment, symptom scores of the DAREN treated cases were significantly lower. Especially during the first burst of cedar grains, the patients, who received DAREN for 2 weeks remained almost asymptomatic. Treatment for Japanese cedar pollinosis was administered according to information from the pollen forecast. It was effective that to have anti-allergic drugs from the first appearence of grains to a week before the first burst.