A Case of Eosinophilic Granuloma

Abstract

Eosinophilic granuloma of the maxilla is rarely seen in Japan. Eosinophilic granuloma of the bone is a category of Histiocytosis X, along with Hand-Schtiller-Christian disease and Letterer-Siwe disease. The histiocytic cell common to these diseases is known as the Langerhans-cell. A recent study concluded that the disease would more aptly be named Langerhans' cell histiocytoma, as opposed to Histiocytosis X. Although Histiocytosis X includes eosinophilic granuloma of the bone, Hand-Schiiller-Christian disease and Letterer-Siwe disease, not all cases fall neatly into one of these three categories; some show mixed symptoms. To respond to this issue, a staging system prepared by Greenberger takes the age factor into consideration. Our case involved a seven-yearold girl who retained symptoms in the right maxilla, frontal scalp, umbilicus and vulvar area. She was classified in Greenberger stage II. For treatment, we administered a combination of vincristine and predonine. This was followed by chemotherapy given through 6MP, resulting in a disappearance of the symptoms. It is now three years since the chemotherapy was conducted, and there has been no recurrence of the symptoms.