Detection of Epstein-Barr Virus in Hodgkin's Lymphoma
1995 Volume 1995 Issue Supplement85 Pages 140-144
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1995 Volume 1995 Issue Supplement85 Pages 140-144
In 13 cases of Hodgkin's lymphoma, which consisted of 4 MC subtypes and 9 NS subtypes, expression of both latent and replicative markers were examined by in situ hybridization and immunohistochemical analysis. In three specimens, EBERs(EBV-encoded small RNAs) and LMP(latent membrane protein) were detected on Reed-Sternberg and Hodgkin cells, although, neither BHLF1 (BamH1 Left Frame 1)mRNA nor BZLF1(BamHl Left Frame 1) protein were detected in any case, indicating that these patients had latent EBV infection. EBNA2(EBV-associated nuclear antigen 2) was not detected in EBERs positive cases, indicating that these patients were in the Latency-2 state with nasopharyngeal carcinoma. Although the etiological role of EBV remains unknown, association of this virus was confirmed in some cases of Hodgkin's disease.
