Clinical Effects of Ryo-kan-kyo-mi-shin-ge-nin-to in the Treatment of Allergic Rhinitis

Abstract

Sho-seiryu-to is often used to treat allergic rhinitis. In this study, we evaluated the effects of Ryo-kan-kyo-mi-shin-ge-nin-to in patients whose symptoms were not improved following treatment with the former drug. The subjects included 22 patients diagnosed with nasal allergy, comprising 11 men and 11 women with a mean age of 46.3 years. The medicine was administered regardless of symptoms, and the patient's condition before administration was compared with that two weeks after administration. Overall,27% of the subjects reported a moderate or better improvement. Evaluation of specific symptoms revealed that paroxysmal sneezes improved in 72% of the patients, asal discharge in 65%, nasal obstruction in 58%; and dysosmia in 14%. A total of 53% ofn the subjects found that their daily life was impeded. No side effects were reported. The efficacy of the medicine appeared to be higher among patients whose the nasal mucosa was pink in color. Thus, the color of the nasal mucosa is thought to be an important factor in selecting the appropriate drug. It was deemed worthwhile to prescribe Ryo-kan-kyo-mi-shin-ge-nin-to to patients in whom Shoseiryuto had proven to be ineffective.