Intratympanic Gentamicin for Meniere's Disease

Abstract

To review the literature relating to intratympanic gentamicin injection therapy for Meniere's disease to detect consistencies and differences that might suggest optimal technique. Twenty-seven papers from the literature regarding clinical experience with intratympanic gentamicin injections for treatment of Meniere's disease were reviewed and tabulated. All papers reported high success rate in treating episodic vertigo of Meniere's disease, but technique, dose, duration, and treatment philosophy varied considerably. Hearing loss was typically reported in about 26% of patients. Based on our review, a titration protocol may be most suitable. The dose should be less than 10 mg at each administration and total dose should be less than 50 mg.